MIC 208 = Virology (Baltimore Classification)

BALTIMORE CLASSIFICATION

1.      Definition

Ø  The Baltimore classification, developed by David Baltimore, is a virus classification system that groups viruses into families, depending on their type of genome (DNA, RNA, single-stranded (ss), double-stranded (ds), etc.) and their method of replication.  This is also found in 1971 that was group by seven class of Baltimore Classification.

2.      Advantages of Baltimore Classification

Ø  Encompasses all viruses

Ø  Based on the viral genome and its relationship to mRNA, modes of replication and gene expression.

Ø  Can make inferences and predictions about the fundamental nature of all viruses within each defined group.

Ø  Can classify between the (+) strand RNA viruses that do (Class VI) and do not (Class IV) undergo reverse transcription.

3.      Baltimore Classification of virus including Class, Virus family, Stranded, Shaped, Example and Diseases

Class	Virus Family	Examples	Nucleic Acid Type	Shaped	Virion Naked/ Enveloped	Diseases
I	Adenoviridae	Adenovirus	DS DNA	Icosahedral	Naked	Respiratory Infection
	Papovaviridae	Papova virus	DS DNA	Icosahedral	Naked	Cancer
	Herpesviridae	Varicella-Zoster virus	DS DNA	Icosahedral	Enveloped	Chicken Pox
	Poxviridae	Smallpox virus	DS DNA	Complex	Complex coats	Small pox
	Irdoviridae	Irdovirus	DS DNA	Icosahedral	Enveloped	Small Iridescent Insect
II	Parvoviridae	Canine Parvovirus	SS DNA	Icosahedral	Naked	a mild rash illness
III	Reoviridae	Reovirus	DS RNA + sense	Icosahedral	Naked	Gastroenteritis in infant
IV	Picornaviridae	Hepatovirus	SS RNA + sense	Icosahedral	Naked	Hepatitis A
	Togaviridae	Rubella virus	SS RNA + sense	Icosahedral	Enveloped	Rubella
	Caliciviridae	Hepatitis E virus	SS RNA + sense	Icosahedral	Naked	Hepatitis E
	Flaviviridae	Dengue virus, Yellow fever virus	SS RNA + sense	Icosahedral	Enveloped	Dengue, Yellow fever
	Coronaviridae	Corona virus	SS RNA + sense	Helical	Enveloped	SARS (Severe Acute Respiratory Syndrome)
V	Rhabdoviridae	Rabies virus	SS RNA - sense	Helical	Enveloped	Rabies disease
	Filoviridae	Ebola virus, Marburg virus	SS RNA - sense	Helical	Enveloped	Ebola, Marburg
	Paramyxoviridae	Mumps virus, nipah virus	SS RNA - sense	Helical	Enveloped	Nipah disease
	Orthomyxoviridae	Influenza virus A,B & C	SS RNA - sense	Helical	Enveloped	Influenza
	Bunyaviridae	Nairo virus	SS RNA - sense	Helical	Enveloped	Nairobi Sheep disease
	Arenaviridae	Arena virus	SS RNA - sense	Complex	Enveloped	Lassa fever
VI	Retroviridae	HIV virus	SS RNA + sense	Spherical	Enveloped	Aids
VII	Hepadnaviridae	Hepatitis B virus	DS DNA	Icosahedral	Enveloped	Hepatitis B